Triclinic Labs offers complete Powder Characterization Services on certified and calibrated equipment to assist you in characterizing your materials. We utilize surface science to assess surface, physical and chemical properties as well as develop strategies for formulation with emphasis on dry powder functionality either for oral or inhaler dosage forms. We have experience with tablets, hard and soft gelatin capsules, solid dispersions, and self-emulsifying systems.We specialize in analysis of physico-chemical properties of powders and interactions among powders (agglomeration and segregation) as well as surface properties as they relate to functionality of drugs and excipients.Tere Carvajal, Ph.D leads Triclinic's Powder Characterization group.
Our characterization services allow you to:
- Investigate particle-particle interactions and interactions of water vapor with different surfaces
- Understanding agglomeration and flow of particles
- Understanding adhesion of particles to processing equipment, substrates
- Quantify the effects of surface variability on product’s functionality in order to establish meaningful criterion for acceptance
- Access stability during formulation processing and storage
- Understand Processes and Particle Phenomena induced by
- Milling
- Fracture & Disorder
- Drying
- Hot Melt Extrusion
- Spray-drying
- Powder Flow and
- Segregation and Agglomeration
- Stability and Performance
- Solubilization and Dispersability
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From particle size analysis to flow characterization, our analytical laboratory provides you with complete analysis and reports tailored to your needs. Our analytical capabilities include:
Full powder characterization including:
- Particle size analysis using Cilas Laser diffraction analyzer (0.7-400µm)
- Light scattering analysis (0.04-200µm)
- Sieve analysis
- Air jet sieve
- Rototap
- X-Ray sedimentation analysis (0.01 microns - 50 microns)
- Aerated and packed bulk density
- Angle of repose, angle of spatula, cohesion, uniformity
- Contact Angle Measurement
- Water Uptake (water isotherms) and Moisture analysis
- Microscopy (optical, SEM)
- Surface energy analysis
Ask us about:
- Blending and milling analysis using novel technologies (IGC, AFM, SEM, Confocal microscopy, DMA, vapor sorption, XPS and spectroscopy).
- Sensor (NIR and Raman) usage in PAT approaches for assessing blend homogeneity and sameness of milled materials.
- Controlling materials, formulation, and processes to comply with the FDA PAT initiative of quality-by-design.
Figure 1. A batch of active before and after milling that passed all required physicochemical tests according to specifications but did not flow as other batches in the mill (i.e. completely clogged the mill). We can utilize particle characterization to determine how early we can anticipate deviations from desired powder behavior upon milling, and avoid them.
From the “The impact of water adsorption on the energetics of surface interactions of various powders.” in Water Properties of Food, Pharmaceutical and Biological Materials,, pp. 639-645 (2006). Carvajal
Register for our on-line seminar on "Powder Technology for Oral Dosage Forms or Inhalation."
